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Axsome’s expectation that AXS-05 can win market share from Rexulti is partly built on the belief that the drug candidate has a differentiated safety profile. Rexulti has a boxed warning because of an increased risk of death. There were no deaths in the AXS-05 trials. Jeffrey Cummings, a research professor at the University of Nevada, Las Vegas, discussed what may happen if AXS-05 avoids a boxed warning.

Axsome Therapeutics said on Monday it would seek marketing approval next year for its oral drug to treat agitation in patients with Alzheimer’s disease, after it succeeded in three out of four late-stage studies.

Today, Axsome will host a conference call and webcast to discuss these topline results. Dr. Jeffrey Cummings, Vice Chair of Research at ºÚÁÏÍø Department of Brain Health, will join the call and be available for questions.

Walking is one of the simplest and most accessible physical activities, but what happens when the movement is reversed? Backward walking, or retro walking, is a practice that is establishing itself in the world of fitness thanks to its unique benefits. Although it may seem like a modern trend, this technique has ancient origins: it was in fact used in Chinese medicine to improve body balance.

Cleveland Clinic Genome Center researchers have unraveled how microglia, which perform key neuroprotective activities, also can transform and drive harmful processes such as inflammation in Alzheimer’s disease.

Eating? That comes naturally for Americans of just about any demographic or age group. Eating nutritionally? That takes some attention, particularly for older Americans, who face healthy eating challenges, both medical and practical, that their younger counterparts may not.

Physiotherapist reveals benefits of walking backwards

The Food and Drug Administration (FDA) has granted 510(k) clearance to Icobrain Aria (Icometrix, Boston, MA), a software that provides computer-assisted, automatic detection and severity grading for amyloid-related imaging abnormalities (ARIA). Icobrain Aria generates a quantitative summary report for MRI images, including severity rating scores based on the measurement and summarization of ARIA cerebral edema (ARIA-E) and ARIA cerebral microhemorrhages (ARIA-H) sites of involvement.

Is arch pain putting a serious damper on your running game? If so, it’s time to hit the sneaker shop (IRL or virtually!) to find the best running shoes for plantar fasciitis. To make sure we covered all the bases for those suffering from the sometimes chronic foot condition, we talked to four experts, including two podiatrists, and put some of their picks to the test ourselves.

Is arch pain putting a serious damper on your running game? If so, it’s time to hit the sneaker shop (IRL or virtually!) to find the best running shoes for plantar fasciitis. To make sure we covered all the bases for those suffering from the sometimes chronic foot condition, we talked to four experts, including two podiatrists, and put some of their picks to the test ourselves.

On Nov. 7, 2024, the U.S. Food and Drug Administration (FDA) granted icometrix clearance for icobrain aria, the first AI software approved for detecting, measuring and grading amyloid-related imaging abnormalities (ARIA), a potentially harmful side effect of new amyloid-targeting therapies. A large study, needed for FDA clearance, demonstrated that the use of icobrain aria significantly increases the accuracy of ARIA assessments by radiologists and hence allows for safer use of new amyloid-beta targeting therapies for Alzheimer’s disease patients.

When it comes to building strength, we often focus on just the muscles. But lurking behind every powerful movement is an unsung network of connective tissues: the ligaments, tendons, and joints that keep our bodies in motion.